Sensitization of Smooth Muscle to the Action of Plasma. BradykininPotentiating Factor. The Action of Hypotensive Polypeptides on the Pulmo. Venoconstriction Induced by Bradykinin in the Rabbit. Cardiovascular Actions of Physalaemin. Hemodynamic Effects of Physalaemin and of Some Syn. Characterization of Kinins in Wasp Venom.
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Studies of Bovine Plasma Kininogen Ornithokallikrein. Enzymatic Kinin Release from Kininogen and from Low. Physiological Influence on the Liberation of Human Plas. Purification and Properties of Bradykininogen and of.
Studies of the Specificity of KininForming Enzymes. Demonstration of the Presence of Two Separate Kinin. Human Salivary Kallikrein and Liberation of Colostro.
Immunologic Studies of Components of the Kallikrein. Kininogenases Kininases and Their Inhibitors. Inactivation and Potentiation of the Effects of Bradykinin.
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The Physiological and Pathological Role of the Kalli. Kallikrein and Vasodilatation in the Salivary Gland. Further Experiments on the Role of Human Plasma. The flags indicate which authority file had at least some publications from the country or region :. Publication Statistics Publication History Send us a comment. About VIAF. Guido Melli.
Bradykinin and its precursor proceedings of the 3rd symposium, held in Florence on 14th June, Clinical pharmacology of serotonin : proceedings of the Satellite Symposium on the Clinical Pharmacology of Serotonin, Helsinki, July , Clinical Implications: Parental CVD status is an important factor influencing the probability of heart murmurs and their intensity in offspring.
The results of this study indicate that CVD development is a polygenic threshold trait and that sex of the offspring influences threshold levels. Heart rate variability in relation to severity of mitral regurgitation in Cavalier King Charles spaniels. J Small Anim Pract. Quote: "Heart rate variability was measured in 81 Cavalier King Charles spaniels to investigate if it could be used to evaluate the severity of mitral regurgitation and to predict decompensation.
Heart rate variability was assessed by the natural logarithm of the variance of the R-R intervals for 20 consecutive beats obtained from electrocardiographic recordings. Twenty-two of the dogs were clinically normal and 59 had mitral regurgitation caused by chronic valvular disease. The severity of mitral regurgitation was evaluated by echocardiography and thoracic radiography. No significant differences in heart rate variability were found among normal dogs, dogs with only cardiac murmur, and dogs with echoradiographic evidence of slight to moderate left atrial and ventricular dilatation.
Multiregression analysis showed that, in order of importance, heart rate, left atrial diameter and respiratory rate had significant effects on heart rate variability. Among these parameters, heart rate variability and left atrial diameter were found to be most efficient in separating decompensated dogs from compensated. It is concluded that heart rate variability may provide the clinician with valuable information when assessing the severity of mitral regurgitation caused by chronic valvular disease.
Epidemiological study of blood pressure in domestic dogs. March ; — Quote: "Previous experience has shown that a noninvasive indirect technique using an oscillomet-ric monitor in conjunction with a tail cuff makes routine clinical blood pressure measurement practicable in dogs. The relationship between indirect and direct readings has been evaluated in both anaesthetised and conscious dogs Bodey and others , In this study, more than pressure measurements were taken from dogs. It was found that systolic is the most variable pressure parameter and that it depends on age, breed, sex, temperament, disease state, exercise regime and, to a minor extent, diet.
Diet was not a significant determinant of diastolic and mean arterial pressure. Age and breed were the major predictors for all parameters. Heart rate was primarily affected by the temperament of the animal, though other factors also play a part in prediction. The distribution of systolic, diastolic, mean arterial pressure and heart rate across the dog population approximates to a log normal distribution. On the basis of these results it is possible to describe normal ranges for canine blood pressure; definition of hypertension, though, demands attention to age and breed normal values.
The existence of statistically defined hypertension in an individual or breed does not imply adverse effects justifying therapy. Among the secondary causes of hypertension, such as diabetes, obesity and hyperadrenocorticism, hepatic disease was a new addition also undocumented in humans. The hypothesis that dogs, though classic model animals for hypertension, are resistant to its development found support from the modest increase in mean pressure values observed among dogs with renal disease, notably those with substantial reduction of glomerular filtration rate.
The pharmacology of neurokinin receptors in addiction: prospects for therapy
The existence of breeds such as deerhounds with average pressures in the borderline range for hypertension in humans and many individuals, therefore, well above suggests that dogs may also be resistant to some of the adverse effects of high blood pressure. Cavalier About Cavalier Heart Disease? Minors S. Thesis, Swedish Univ.
The problem of inherited diseases. Swift, S. Small Animal Prac. Comparison of the effects of levosimendan, pimobendan, and milrinone on canine left ventricular-arterial coupling and mechanical efficiency. July ;91 4 The results indicate that levosimendan, pimobendan, and milrinone augment myocardial contractility, produce venous and arteriolar vasodilation, and enhance LV-arterial coupling and mechanical efficiency in open-chest, barbiturate-anesthetized dogs. Port-access mitral valve replacement in dogs.
J Thorac Cardiovasc Surg ; — Effects of enalapril on exercise tolerance and longevity in dogs with heart failure produced by iatrogenic mitral regurgitation. J Vet Intern Med ; Darke, P. Swenson L. November Effects of long-term treatment with enalapril or hydralazine on the reninangiotensin-aldosterone system and fluid balance in dogs with naturally acquired mitral valve regurgitation. Amer J Vet Res. November ; Quote: Objective: To study long-term effects of enalapril, an angiotensin-converting enzyme inhibitor, and hydralazine, an arteriodilator, on renin-angiotensin-aldosterone system and fluid balance before and after administration of furosemide.
Animals: 22 dogs with clinical signs of congestive heart failure CHF attributable to mitral regurgitation. Procedure: After initial examination, 12 dogs received enalapril and 10 received hydralazine. Dogs were re-examined 3 weeks and 6 months after initial examination. Furosemide was added after the 3-week examination, and at 6 months, dogs had received furosemide for at least 4 months.
Results: Angiotensin II and aldosterone plasma concentrations were low before treatment, and only aldosterone became significantly decreased after enalapril monotherapy. Concentrations of both hormones and heart rate increased in dogs receiving hydralazine monotherapy, and fluid retention was evident.
After long-term treatment with either of the 2 drugs together with furosemide, angiotensin II and aldosterone values increased in both groups. Natriuresis and kaliuresis developed in all dogs, with greatest effect in those receiving enalapril and furosemide. These dogs had decreased plasma sodium concentration, whereas potassium concentration was equally decreased in both groups. After 6 months, the enalapril group, but not the hydralazine group, had increased cardiac size. All dogs had moderate reduction of weight and were azotemic, although changes were more pronounced in those of the hydralazine group.
Conclusion: The 2 drugs have different effects on the renin-angiotensin-aldosterone system and fluid balance in dogs with CHF.
nitsesamimo.ga Doppler echocardiographic index for assessment of global right ventricular function. Chuwa Tei, Karl S. Dujardin, David O. Hodge, Kent R. Bailey, Michael D. McGoon, A. Jamil Tajik, James B. November ;9 6 Quote: "The purpose of this study was to assess the clinical value of a Doppler-derived index, combining systolic and diastolic intervals of the right cycle, in assessing global right ventricular function in patients with primary pulmonary hypertension. It is well known that right ventricular systolic and diastolic dysfunction coexist in patients with primary pulmonary hypertension.
This article reports the use of an easily obtainable Doppler-derived index that combines elements of systolic and diastolic function. This index appears to be a useful noninvasive means that correlates with symptoms and survival in patients with primary pulmonary hypertension.
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Effects of naturally acquired decompensated mitral valve regurgitation on the renin-angiotensin-aldosterone system and atrial natriuretic peptide concentration in dogs. January ;58 1 Quote: Objective: To investigate activity of the renin-angiotensin-aldosterone system and N-terminal pro-atrial natriuretic peptide NT-proANP during development of clinical signs of decompensated mitral valve regurgitation MR. Procedure: Dogs were subjected to repeated examinations at 6-month intervals until signs of decompensation had developed end point.
Data acquired at end point were compared with data obtained from examinations 1 year and 1 to 6 months before decompensation. Each examination included physical examination, collection of venous blood, thoracic radiography, and echocardiography. Results: Echocardiographic measurements of left atrial-to-aortic root ratio and left ventricular end diastolic diameter increased considerably during the study, whereas left ventricular end systolic diameter remained unchanged.
In contrast, plasma concentrations of aldosterone and angiotensin II were reduced at decompensation aldosterone compared with the 2 earlier examinations and angiotensin II compared with values obtained 1 to 6 months before , despite decreased plasma protein concentration and hematocrit, suggesting fluid retention. The urine-to-plasma creatinine ratio was reduced at end point.
Update on Mitral Valve Disease. Jacobs G. Results of the multicenter spaniel trial MUST : taurine- and carnitine-responsive dilated cardiomyopathy in American cocker spaniels with decreased plasma taurine concentration. J Vet Intern Med;July ;11 4 Quote: "Fourteen American Cocker Spaniels ACS with dilated cardiomyopathy DCM were studied to determine if individuals of this breed with DCM are systemically taurine- or carnitine-deficient and to determine if they are responsive to taurine and carnitine supplementation.